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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/68670

    Título
    Investigating the prognostic role of peripheral inflammatory markers in mild cognitive impairment
    Autor
    Tondo, Giacomo
    Aprile, Davide
    De Marchi, Fabiola
    Sarasso, Barbara
    Serra, Paola
    Borasio, Giordana
    Rojo Martínez, Esther
    Arenillas Lara, Juan FranciscoAutoridad UVA
    Comi, Cristoforo
    Año del Documento
    2023
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Clinical Medicine, 2023, Vol. 12, Nº. 13, 4298
    Zusammenfassung
    Growing evidence suggests that neuroinflammation plays a critical role in the pathogenesis of neurodegenerative diseases. Peripheral markers of inflammation, including blood cell counts and their ratios, such as the neutrophil-to-lymphocyte ratio (NLR), have been reported as an easily accessible and reliable proxy of central nervous system inflammation. However, the role of peripheral inflammation in dementia and Mild Cognitive Impairment (MCI) still needs to be clarified. In the current study, we aimed to assess the prognostic role of the NLR and other peripheral markers of inflammation in a sample of 130 amnestic MCI, followed up for two to five years. The Mini-Mental state examination (MMSE) score at baseline and follow-up visits was used to assess global cognitive status at each visit and the degree of cognitive decline over time. Baseline peripheral markers of inflammation included blood cell counts and ratios, specifically the NLR, the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR), and the systemic immune inflammation index (SII). After classifying subjects into CONVERTERS and non-CONVERTERS (respectively, patients converting to dementia and subjects showing stability at the last available follow-up), we compared peripheral markers of inflammation among groups ed correlated them with cognitive measures, testing the ability of significant factors to predict conversion to dementia. In our cohort, CONVERTERS showed lower baseline MMSE scores (p-value = 0.004) than non-CONVERTERS. In addition, CONVERTERS had statistically elevated NLR (p-value = 0.005), PLR (p-value = 0.002), and SII levels (p-value = 0.015), besides a lower number of lymphocytes (p-value = 0.004) compared with non-CONVERTERS. In a logistic regression analysis, baseline MMSE scores and NLR predicted conversion to dementia. Tertiles analysis showed that MCI with the highest NLR values had a higher conversion risk. Our study supports the hypothesis that a dysregulation of peripheral inflammation involving both lymphocytes and neutrophils may play a role in the pathogenesis of dementia, even at the early stages of neurodegeneration, as in the MCI condition.
    Materias (normalizadas)
    Cognition disorders
    Mild Cognitive Impairment
    Dementia
    Demencia
    Nervous system - Degeneration
    Sistema nervioso - Degeneración
    Neurology
    Neurology
    Neuroimmunology
    Neuroinmunología
    Inflammation
    Inflamación
    Clinical medicine
    Materias Unesco
    32 Ciencias Médicas
    3205.07 Neurología
    6104.01 Procesos Cognitivos
    ISSN
    2077-0383
    Revisión por pares
    SI
    DOI
    10.3390/jcm12134298
    Nota
    El estudio fue apoyado por el Proyecto AGING del Departamento de Medicina Traslacional (DIMET) de la Universidad del Piamonte Oriental, Novara, Italia
    Version del Editor
    https://www.mdpi.com/2077-0383/12/13/4298
    Propietario de los Derechos
    © 2023 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/68670
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [184]
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    Investigating-the-Prognostic-Role-of-Peripheral-Inflammatory-Markers.pdf
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