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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/68942

    Título
    Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
    Autor
    Coco Martín, Rosa MaríaAutoridad UVA Orcid
    Belani Raju, Minal
    Fuente Gómez, Daniel de la
    Sanabria Ruiz Colmenares, María RosaAutoridad UVA Orcid
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Año del Documento
    2020-01
    Editorial
    Springer Nature
    Documento Fuente
    Graefes Arch Clin Exp Ophthalmol, Jan, 2021, vol. 259, n. 1, p. 81-92.
    Resumen
    ABSTRACT. PURPOSE This study aims to determine the probability of progression of myopic maculopathy according to age. METHODS This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measures were age, visual acuity (VA), refractive error (RE), follow-up time, and the macular status assessed at least 5 years apart according to the Meta-Analysis of Pathologic Myopia Study Group. The progression rate was calculated based on per 1000 eyes/year.Multistate models were fitted to identify the predictive factors and to calculate the most probable age of progression onset using the Aalen–Johansen estimator. RESULTS We studied 220 eyes of 122 Caucasian patients. Mean age was 48.18 ± 14.1, mean follow-up 12.73 ± 5.81 years. One hundred and fifty-two (69.1%) eyes progressed of category, and 96 (44%) worsened a mean of 0.3 logMAR units during followup. The progression rate was 32.21/1000 eyes/year. The probability of progressing increased with age; it was higher in women if there was a family history of myopia, worse VA, higher RE, or wide macular staphyloma. The probability of progressing from category 1 was > 0.6 after 70 years of age; from category 2, it was 0.7 after 70 years; and 0.5 from category 3 after 75 years. If choroidal neovascularization (CNV) appeared, this probability exceeded 0.7 between ages 45 and 55 for all categories. CONCLUSION The progression rate is lower than in a Japanese series. The vision worsened with disease progression, and the probability of both happening increased after the age of 70–75. If CNV appears, the risk of progression is very high at the age of 45–55.
    Materias Unesco
    3201.09 Oftalmología
    Palabras Clave
    Choroidal neovascularization; High myopia; Lacquer cracks; Multistate models; Myopic maculopathy; Pathologic myopia; Risk factors of progression
    ISSN
    0721-832X
    Revisión por pares
    SI
    DOI
    10.1007/s00417-020-04795-5
    Version del Editor
    https://link.springer.com/article/10.1007/s00417-020-04795-5
    Propietario de los Derechos
    Springer
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/68942
    Tipo de versión
    info:eu-repo/semantics/submittedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • Retina - Artículos de Revista [13]
    • IOBA - Artículos de revista [80]
    • DEP11 - Artículos de revista [242]
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