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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/70243

    Título
    Pumping up the fight against multiple sclerosis: the effects of high-intensity resistance training on functional capacity, muscle mass, and axonal damage
    Autor
    Maroto Izquierdo, Sergio
    Mulero Carrillo, Patricia
    Menéndez, Héctor
    Pinto Fraga, Francisco JoséAutoridad UVA Orcid
    Lista, Simone
    Santos Lozano, Alejandro
    Téllez Lara, María de las NievesAutoridad UVA
    Año del Documento
    2024
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Healthcare, 2024, Vol. 12, Nº. 8, 837
    Resumen
    Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients.
    Materias (normalizadas)
    Neurosciences
    Neurodegeneration
    Nervous system - Diseases
    Nervioso, Sistema - Enfermedades
    Exercise
    Ejercicio físico
    Sports - Physiological aspects
    Deportes - Aspectos fisiológicos
    Sport Training
    Entrenamiento (Deportes)
    Muscle hypertrophy
    Cuerpo humano - Hipertrofia
    Physical function
    Multiple sclerosis
    Esclerosis lateral amiotrófica
    Medicine
    Neurology
    Public health
    Materias Unesco
    2490 Neurociencias
    32 Ciencias Médicas
    3205.07 Neurología
    2411.06 Fisiología del Ejercicio
    3212 Salud Publica
    ISSN
    2227-9032
    Revisión por pares
    SI
    DOI
    10.3390/healthcare12080837
    Version del Editor
    https://www.mdpi.com/2227-9032/12/8/837
    Propietario de los Derechos
    © 2024 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/70243
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP52 - Artículos de revista [181]
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