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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/70985

    Título
    Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study
    Autor
    Martín Escudero, Juan CarlosAutoridad UVA
    Chaves, Felipe Javier
    García García, Ana Bárbara
    Martín Vallejo, Javier
    García Sorribes, Soraya
    Lara Hernández, Francisco
    Abadia Otero, JesicaAutoridad UVA Orcid
    Briongos Figuero, Laisa SocorroAutoridad UVA Orcid
    Pérez Castrillon, José LuisAutoridad UVA
    Usategui Martín, RicardoAutoridad UVA Orcid
    Año del Documento
    2022
    Editorial
    IMR Press
    Documento Fuente
    Front Biosci (Landmark Ed). 2022 Jan 18;27(1):32
    Resumen
    Background: Osteoporosis and obesity are major public health problems that are closely correlated, as they share various features, including a genetic predisposition. A genetic correlation between obesity and osteoporosis due to the biological common pathways of bone and fat metabolism, which implies pleiotropic genes regulating has been described. The objective of our study was to analyse whether polymorphisms in obesity-related genes modify the risk of osteoporotic bone fracture. Methods: We studied 575 subjects from the Hortega Study. The subjects were followed-up for 12-14 years. 202 subjects were overweight, 143 obese and 221 had bone fractures. The distribution of 39 genetic variants in 22 obesity-related genes were studied. Results: The results showed a relationship between polymorphisms in the FTO and NEGR1 genes and the susceptibility to osteoporotic fracture. The variant genotype of the rs2568958 NEGR1 polymorphism and the rs6499649, rs3751812, and rs8044769 genetic variants in FTO were associated with susceptibility to bone fracture. In the best of our knowledge, this is the first time that these variants in NEGR1 and FTO genes have been associated with the susceptibility to osteoporotic bone fracture, supporting the hypothesis that the NEGR1 and FTO genes might be candidates for osteoporosis and bone fracture. Conclusions: In conclusion, this study associates obesity-related polymorphisms in the NEGR1 and FTO genes with osteoporotic bone fracture, reinforcing the hypothesis that obesity and bone metabolism are closely correlated genetically.
    Palabras Clave
    Bone fracture; FTO and NEGR1; Obesity; Osteoporosis; Polymorphism.
    ISSN
    2768-6701
    Revisión por pares
    SI
    DOI
    10.31083/j.fbl2701032
    Version del Editor
    https://www.imrpress.com/journal/FBL/27/1/10.31083/j.fbl2701032/htm
    Propietario de los Derechos
    © 2022 The Author(s)
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/70985
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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