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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/76898

    Título
    High‐Dimensional Immunophenotyping of Post‐COVID‐19 and Post‐Influenza Patients Reveals Persistent and Specific Immune Signatures After Acute Respiratory Infection
    Autor
    Pérez‐Cózar, Francisco
    Cal‐Sabater, Paloma
    Rybakowska, Paulina
    Arribas‐Rodríguez, Elisa
    Fiz‐López, Aida
    García‐Blesa, Antonio
    Hernández, Juan
    Gutiérrez, Sara
    Tellería, Pablo
    Novoa, Cristina
    Rello, Silvia Rojo
    De Prado, Ángel
    Pérez, Cándido
    Sedano, Rosa
    Domínguez‐Gil, Marta
    Peñarrubia, María Jesús
    Pieren, Daan K. J.
    Garrote, José A.
    Arranz, Eduardo
    Eiros, José María
    Tamayo, Eduardo
    Orduña, Antonio
    van Els, Cécile A.C.M.
    Dueñas, Carlos
    Marañón, Concepción
    Bernardo, David
    Cuesta‐Sancho, Sara
    Año del Documento
    2025
    Editorial
    Wiley
    Descripción
    Producción Científica
    Documento Fuente
    Journal of medical virology, junio 2025, 97. e70435
    Resumen
    Long-term consequences of SARS-CoV-2 infection are unknown since recovered individuals can experience symptoms and latent viral reactivation for months. Indeed, acute post-infection sequelae have also been observed in other respiratory viral infections, including influenza. To characterize post-COVID-19 and post-influenza induced alterations to the cellular immunome, peripheral blood mononuclear cells (PBMCs) were obtained from patients 3 months after recovery from COVID-19 (n = 93) or influenza (n = 25), and from pre-pandemic healthy controls (n = 25). PBMCs were characterized using a 40-plex mass cytometry panel. Principal component analysis (PCA), classification models, and K-means clustering were subsequently applied. PCA identified distinct immune profiles between cohorts, with both post-COVID and post-flu patients displaying an altered chemokine receptor expression compared to pre-pandemic healthy controls. These alterations were more prominent in post-COVID patients since they exhibited highly increased expression of chemokine receptors CXCR3 and CCR6 by various lymphoid populations, while post-influenza patients mainly showed a decrease in CCR4 expression by naïve T cells, monocytes, and conventional dendritic cells. Classification models using immunophenotyping data confirm the three groups, while K-means clustering revealed two subgroups among post-COVID patients, with younger patients showing more pronounced immune alterations in the chemokine receptor profile, independently of long COVID symptoms. In conclusion, post-COVID and post-influenza patients exhibit distinct and unique persistent immune alterations. Understanding these altered immune profiles can guide targeted therapies for post-COVID syndrome and highlight differences in immune recovery from various respiratory infections.
    Materias (normalizadas)
    Inmunoterapia
    Covid-19 (Enfermedad)
    Materias Unesco
    2412 Inmunología
    3202 Epidemiología
    Palabras Clave
    Immune signature
    Immunome
    Post‐COVID‐19
    Post‐influenza
    ISSN
    0146-6615
    Revisión por pares
    SI
    DOI
    10.1002/jmv.70435
    Version del Editor
    https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.70435
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/76898
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP55 - Artículos de revista [213]
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