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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/21591
Title: MEG analysis of neural dynamics in attention-deficit/hyperactivity disorder with fuzzy entropy
Authors: Monge, Jesús
Gómez Peña, Carlos
Poza Crespo, Jesús
Fernández, Alberto
Quintero, Javier
Hornero Sánchez, Roberto
Issue Date: 2015
Publisher: Elsevier
Description: Producción Científica
Citation: Medical Engineering and Physics 37 (2015) 416–423
Abstract: The aim of this study was to analyze the neural dynamics in attention-deficit/hyperactivity disorder (ADHD). For this purpose, magnetoencephalographic (MEG) background activity was analyzed using fuzzy entropy (FuzzyEn), an entropy measure that quantifies signal irregularity, in 13 ADHD patients and 14 control children. Additionally, relative power (RP) was computed in conventional frequency bands (delta, theta, alpha, beta and gamma). FuzzyEn results showed that MEG activity was more regular in ADHD patients than in controls. Moreover, we found an increase of power in delta band and a decrease in the remaining frequency bands. Statistically significant differences (p-values <0.05; nonparametric permutation test for multiple comparisons) were detected for FuzzyEn in the posterior and left temporal regions, and for RP in the posterior, anterior and left temporal regions. Our results support the hypothesis that ADHD involves widespread functional brain abnormalities, affecting more areas than fronto-striatal circuits, such as the left temporal and posterior regions.
Keywords: Attention-deficit/hyperactivitydisorder
ISSN: 1350-4533
Peer Review: SI
DOI: 10.1016/j.medengphy.2015.02.006
Sponsor: Ministerio de Economía y Competitividad (project TEC2011-22987)
Junta de Castilla y León (project BIO/VA38/14 and project VA059U13)
Language: eng
URI: http://uvadoc.uva.es/handle/10324/21591
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP71 - Artículos de revista

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