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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/21595
Título: Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
Autor: Labrador Velandia, Sonia
Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernandez Bueno, Iván
Srivastava, Girish Kumar
Año del Documento: 2016
Editorial: Baishideng Publishing Group
Descripción: Producción Científica
Documento Fuente: World Journal of Stem Cells 2016, 26; 8(11), p. 376-383
Resumen: Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases
Materias (normalizadas): Células madre
Retina
ISSN: 1948-0210
Revisión por Pares: SI
DOI: 10.4252/wjsc.v8.i11.376
Patrocinador: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13)
Version del Editor: http://www.wjgnet.com/1948-0210/index.htm
Propietario de los Derechos: © 2016 Baishideng Publishing Group Inc.
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/21595
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP11 - Artículos de revista

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