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Title: Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
Authors: Labrador Velandia, Sonia
Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernandez Bueno, Iván
Srivastava, Girish Kumar
Issue Date: 2016
Publisher: Baishideng Publishing Group
Description: Producción Científica
Citation: World Journal of Stem Cells 2016, 26; 8(11), p. 376-383
Abstract: Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases
Keywords: Células madre
ISSN: 1948-0210
Peer Review: SI
DOI: 10.4252/wjsc.v8.i11.376
Sponsor: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13)
Publisher Version:
Rights Owner: © 2016 Baishideng Publishing Group Inc.
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP11 - Artículos de revista

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