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Title: 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
Authors: Vila, Mercedes
García, Ana
Girotti, Alessandra
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
González Vázquez, Arlyng
Planell i Estany, Josep A.
Engel López, Elisabeth
Buján Varela, Julia
García Honduvilla, Natalio
Vallet Regí, María
Issue Date: 2016
Publisher: Elsevier
Description: Producción Científica
Citation: Acta Biomaterialia 2016, Elsevier, vol. 45, p. 349–356
Abstract: The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) func- tionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineer- ing: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxya- patite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.
Keywords: Biomateriales - Aplicaciones médicas
ISSN: 1742-7061
Peer Review: SI
Sponsor: Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)
Ministerio de Ciencia e Innovación (proyectos MAT2012-35556 y MAT2009-14195-C03-02)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14)
Programme: info:eu-repo/grantAgreement/EC/H2020/642687
Publisher Version:
Language: eng
Rights: info:eu-repo/semantics/embargoedAccess
Appears in Collections:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
DEP60 - Artículos de revista

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