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Título: The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal
Autor: Muñoz, Luis J.
Carballosa Gautam, Melissa M.
Yanowsky, Kira
García Atarés, Natividad
López, Dolores E.
Año del Documento: 2016
Editorial: Elsevier
Descripción: Producción Científica
Documento Fuente: Epilepsy Behavior
Resumen: GASH:Sal hamster strain and the control Syrian hamsters. The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic–clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem. The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.
Palabras Clave: Epilepsia audiogénica
AFLP
Hamsters
Revisión por Pares: SI
DOI: 10.1016/j.yebeh 2016.03.002
Propietario de los Derechos: Elsevier
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/23318
Derechos: info:eu-repo/semantics/openAccess
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