|Title: ||The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal|
|Authors: ||Muñoz, Luis J.|
Carballosa Gautam, Melissa M.
García Atarés, Natividad
López, Dolores E.
|Issue Date: ||2016|
|Description: ||Producción Científica|
|Citation: ||Epilepsy Behavior|
|Abstract: ||GASH:Sal hamster strain and the control Syrian hamsters.
The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic–clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem.
The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.|
|Classification: ||Epilepsia audiogénica|
|Peer Review: ||SI|
|DOI: ||10.1016/j.yebeh 2016.03.002|
|Rights Owner: ||Elsevier|
|Appears in Collections:||DEP04 - Artículos de revista|