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Título: Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin
Autor: Barriuso, Begoña
Jiménez, Pilar
Cordoba-Diaz, Manuel
Cordoba-Diaz, Damián
Girbés, Tomás
Arias, Francisco Javier
Girotti, Alessandra
Año del Documento: 2016
Editorial: MDPI
Descripción: Producción Científica
Documento Fuente: Toxins vol.8, issue 6, 2016
Resumen: Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10−10 to 10−9 M.
Palabras Clave: Cáncer
Terapia antitumoral
ISSN: 2072-6651
Revisión por Pares: SI
DOI: 10.3390/toxins8060184
Patrocinador: CICYT BIO98-0727
Version del Editor: http://www.mdpi.com/2072-6651/8/6/184
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24415
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:BIOFORGE - Artículos de revista

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