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Title: Anti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin
Authors: Barriuso, Begoña
Jiménez, Pilar
Cordoba-Diaz, Manuel
Cordoba-Diaz, Damián
Girbés, Tomás
Arias, Francisco Javier
Girotti, Alessandra
Issue Date: 2016
Publisher: MDPI
Description: Producción Científica
Citation: Toxins vol.8, issue 6, 2016
Abstract: Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10−10 to 10−9 M.
Classification: Cáncer
Terapia antitumoral
ISSN: 2072-6651
Peer Review: SI
DOI: 10.3390/toxins8060184
Sponsor: CICYT BIO98-0727
Publisher Version:
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:BIOFORGE - Artículos de revista

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