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Título: Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
Autor: Govindharajulu, Jeevan Prasaad
Rodríguez Cabello, José Carlos
Battacharya, Mrinal
Aparicio, Conrado
Año del Documento: 2017
Editorial: MDPI
Descripción: Producción Científica
Documento Fuente: International Journal of Molecular Sciences 2017, 18 (2), 369;
Resumen: The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment
Palabras Clave: Implante dental
Revisión por Pares: SI
DOI: 10.3390/ijms18020369
Patrocinador: Ministerio de Economía, Industria y Competitividad (Project MAT2013-42473-R and MAT2015-68901R)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13, VA313U14 and VA015U16)
Version del Editor: http://www.mdpi.com/journal/ijms
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24420
Derechos: info:eu-repo/semantics/openAccess
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