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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24427

    Título
    Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization
    Autor
    Hamed Misbah, Mohamed
    Santos García, María MercedesAutoridad UVA Orcid
    Quintanilla Sierra, LuisAutoridad UVA
    Günter, Christina
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Taubert, Andreas
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Año del Documento
    2017
    Editorial
    Beilstein-Institut
    Descripción
    Producción Científica
    Documento Fuente
    Beilstein Journal of Nanotechnology, 2017, 8, pg. 772–783
    Resumen
    Understanding the mechanisms responsible for generating different phases and morphologies of calcium phosphate by elastin-like recombinamers is supreme for bioengineering of advanced multifunctional materials. The generation of such multifunctional hybrid materials depends on the properties of their counterparts and the way in which they are assembled. The success of this assembly depends on the different approaches used, such as recombinant DNA technology and click chemistry. In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically bind to and nucleate calcium phosphate. The benefit of using click chemistry is that the hybrid elastin-like-statherin recombinamers cross-link without losing their fibrillar structure. Mineralization of the resulting hybrid elastin-like-statherin recombinamer hydrogels with calcium phosphate is described. Thus, two different hydroxyapatite morphologies (cauliflower- and plate-like) have been formed. Overall, this study shows that crosslinking elastin-like recombinamers leads to interesting matrix materials for the generation of calcium phosphate composites with potential applications as biomaterials.
    Palabras Clave
    Calcio
    Mineralización
    Revisión por pares
    SI
    DOI
    10.3762/bjnano.8.80
    Patrocinador
    Ministerio de Economía, Industria y Competitividad (Project MAT2013- 42473-R and MAT2013-41723-R)
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13, VA313U14 and GRS/516/A/10)
    Patrocinador
    info:eu-repo/grantAgreement/EC/H2020/642687
    info:eu-repo/grantAgreement/EC/H2020/646075
    info:eu-repo/grantAgreement/EC/FP7/278557
    info:eu-repo/grantAgreement/EC/FP7/317306
    Version del Editor
    https://www.beilstein-journals.org/bjnano/articles/8/80
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/24427
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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