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Título: Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
Autor: Singh, Smriti
Rahimi, Khosrow
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
Año del Documento: 2016
Editorial: Royal Society of Chemistry
Descripción: Producción Científica
Documento Fuente: Soft Matter, 2016,12, pg. 6240-6252
Resumen: Investigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.
Palabras Clave: Agregación de microgeles biohíbridos
Revisión por Pares: SI
DOI: 10.1039/C6SM00954A
Patrocinador: info:eu-repo/grantAgreement/EC/H2020/642687
Patrocinador: Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R).
Version del Editor: http://pubs.rsc.org/en/content/articlelanding/2016/sm/c6sm00954a
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24800
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
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