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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/24800
Title: Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
Authors: Singh, Smriti
Rahimi, Khosrow
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
Issue Date: 2016
Publisher: Royal Society of Chemistry
Description: Producción Científica
Citation: Soft Matter, 2016,12, pg. 6240-6252
Abstract: Investigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.
Classification: Agregación de microgeles biohíbridos
Peer Review: SI
DOI: 10.1039/C6SM00954A
Sponsor: Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R).
Programme: info:eu-repo/grantAgreement/EC/H2020/642687
Publisher Version: http://pubs.rsc.org/en/content/articlelanding/2016/sm/c6sm00954a
Language: eng
URI: http://uvadoc.uva.es/handle/10324/24800
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
BIOFORGE - Artículos de revista

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