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Título: Coacervation of Elastin-Like Recombinamer Microgels
Autor: Smriti Singh
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
Año del Documento: 2016
Editorial: Wiley
Descripción: Producción Científica
Documento Fuente: Macromolecular Rapid Communications, 2016, 37, Issue 2, pg.181–186
Resumen: The investigation of the coacervation (self-aggregation) behavior of biomicrogels which can potentially be used as drug carriers is an important topic, because self-aggregation can not only cause loss of activity, but also toxicity and immunogenicity. To study this effect microgels from elastin-like recombinamer are synthesized using miniemulsion technique. The existence of coacervation for such microgels, at different concentrations and temperatures, is studied and proved by cryo-field emission scanning clectron microscopy (cryo-FESEM), cryo-transmission electron microscopy (cryo-TEM), and by a novel 1H high-resolution magic angle sample spinning (HRMAS), nuclear magnetic resonance (NMR) spectroscopy, and relaxometry methods. The findings by 1H HRMAS NMR spectroscopy and relaxometry show simultaneous processes of volume phase temperature transition and coacervation with different sensitivity for hydrophobic and hydrophilic amino acid side-chains in the microgel. The coacervation process is more evidential by the behavior of glycine α-CH2, 1H NMR peak as compared to the proline β-CH2.
Palabras Clave: Microgeles
Revisión por Pares: SI
DOI: 10.1002/marc.201500457
Patrocinador: info:eu-repo/grantAgreement/EC/H2020/642687
Patrocinador: Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)
Version del Editor: http://onlinelibrary.wiley.com/doi/10.1002/marc.201500457/full
Propietario de los Derechos: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/24805
Derechos: info:eu-repo/semantics/openAccess
Embargado hasta2019-12-12
Aparece en las colecciones:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
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