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Title: Coacervation of Elastin-Like Recombinamer Microgels
Authors: Smriti Singh
Fechete, Radu
Rodríguez Cabello, José Carlos
Möller, Martin
Issue Date: 2016
Publisher: Wiley
Description: Producción Científica
Citation: Macromolecular Rapid Communications, 2016, 37, Issue 2, pg.181–186
Abstract: The investigation of the coacervation (self-aggregation) behavior of biomicrogels which can potentially be used as drug carriers is an important topic, because self-aggregation can not only cause loss of activity, but also toxicity and immunogenicity. To study this effect microgels from elastin-like recombinamer are synthesized using miniemulsion technique. The existence of coacervation for such microgels, at different concentrations and temperatures, is studied and proved by cryo-field emission scanning clectron microscopy (cryo-FESEM), cryo-transmission electron microscopy (cryo-TEM), and by a novel 1H high-resolution magic angle sample spinning (HRMAS), nuclear magnetic resonance (NMR) spectroscopy, and relaxometry methods. The findings by 1H HRMAS NMR spectroscopy and relaxometry show simultaneous processes of volume phase temperature transition and coacervation with different sensitivity for hydrophobic and hydrophilic amino acid side-chains in the microgel. The coacervation process is more evidential by the behavior of glycine α-CH2, 1H NMR peak as compared to the proline β-CH2.
Classification: Microgeles
Peer Review: SI
DOI: 10.1002/marc.201500457
Sponsor: Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)
Programme: info:eu-repo/grantAgreement/EC/H2020/642687
Publisher Version:
Rights Owner: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
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