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Title: Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol
Authors: Lopes, Joana
Mustapa, Ana Najwa
Pantic, Milica
Bermejo Roda, Mª Dolores
Martín Martínez, Ángel
Novak, Zoran
Knez, Zeljko
Cocero Alonso, María José
Issue Date: 2017
Publisher: Elsevier B.V.
Description: Producción Científica
Citation: The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22
Abstract: The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.
Keywords: Materiales
Classification: Supercritical
Ionic liquids
ISSN: 0896-8446
Peer Review: SI
DOI: 10.1016/j.supflu.2017.07.018
Sponsor: Junta de Castilla y León VA295U14
Marie Curie Program. Project DoHip
Ministerio de Economía. Programa Ramon y Cajal, RyC RYC-2013-13976
MOE (Ministry of Education of Malaysia)
Publisher Version:
Rights Owner: Elsevier B.V.
Language: eng
Rights: info:eu-repo/semantics/embargoedAccess
Appears in Collections:IPP - Artículos de revista

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