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Título: Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol
Autor: Lopes, Joana
Mustapa, Ana Najwa
Pantic, Milica
Bermejo Roda, Mª Dolores
Martín Martínez, Ángel
Novak, Zoran
Knez, Zeljko
Cocero Alonso, Mª José
Año del Documento: 2017
Editorial: Elsevier B.V.
Descripción: Producción Científica
Documento Fuente: The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22
Resumen: The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.
Materias (normalizadas): Materiales
Palabras Clave: Supercritical
Impregnation
Aerogel
Phytol
Cellulose
Ionic liquids
ISSN: 0896-8446
Revisión por Pares: SI
DOI: 10.1016/j.supflu.2017.07.018
Patrocinador: Junta de Castilla y León VA295U14
Marie Curie Program. Project DoHip
Ministerio de Economía. Programa Ramon y Cajal, RyC RYC-2013-13976
MOE (Ministry of Education of Malaysia)
Version del Editor: https://doi.org/10.1016/j.supflu.2017.07.018
Propietario de los Derechos: Elsevier B.V.
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/26138
Derechos: info:eu-repo/semantics/embargoedAccess
Embargado hasta2019-07-25
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