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Title: Biodegradable Chitosan-Derived Thioureas as Recoverable Supported Organocatalysts – Application to the Stereoselective Aza-Henry Reaction
Authors: Andrés García, José María
González, Fernando
Maestro Fernández, Alicia
Pedrosa Sáez, Rafael
Valle, María
Issue Date: 2017
Publisher: Wiley
Description: Producción Científica
Citation: European Journal of Organic Chemistry, 2017, Volume 2017, Issue 25, Pages 3658–3665
Abstract: Eight different biodegradable chitosan-supported bifunctional chiral thioureas have been prepared as a greener and more sustainable alternative to those supported on petrochemical-derived polymers. These organocatalysts promoted an enantioselective aza-Henry reaction, which afforded good product yields with moderate to high enantioselectivity. The activity and stereodirecting ability of these materials were dependent on the accessibility of the reactants to the active site and increased with the length of the tether that connected the thiourea to the biopolymer. The best performing catalyst was able to be recovered and recycled five times without a loss of activity.
Keywords: Catálisis
Química orgánica
Peer Review: SI
DOI: 10.1002/ejoc.201700582
Sponsor: Ministerio de Economía, Industria y Competitividad (Project CTQ 2014-59870-P)
Publisher Version:
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:CINQUIMA - Artículos de revista
DEP67 - Artículos de revista

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