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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/4574
Título: Embryonic cerebrospinal fluid regulates neuroepithelial survival proliferation and neurogenesis in chick embryos
Autor: Gato Casado, Ángel Luis
Moro Balbás, José Antonio
Alonso Revuelta, María Isabel
Bueno, D.
Mano Bonín, Aníbal de la
Año del Documento: 2005
Editorial: Wiley-Liss
Descripción: Producción Científica
Documento Fuente: The Anatomical record. Part A, 2005, p. 475-484
Resumen: Early in development, the behavior of neuroepithelial cells is controlled by several factors, which act in a developmentally regulated manner. Dif- fusible factors are secreted locally by the neuroepithelium itself, although other nearby structures may also be involved. Evidence suggests a physio- logical role for the cerebrospinal fluid in the development of the brain. Here, using organotypic cultures of chick embryo neuroepithelial explants from the mesencephalon, we show that the neuroepithelium in vitro is not able to self-induce cell survival, replication, and neurogenesis. We also show that the embryonic cerebrospinal fluid (E-CSF) promotes neuroepithelial stem cell survival and induces proliferation and neurogenesis in mesencephalic explants. These data strongly suggest that E-CSF is involved in the regu- lation of neuroepithelial cells behavior, supporting the hypothesis that this fluid plays a key role during the early development of the central nervous system.
Materias (normalizadas): Embriología
Líquido cefalorraquídeo
Neurología
ISSN: 003-276X
Revisión por Pares: SI
DOI: 10.1002/ar.a 20185
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/4574
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP04 - Artículos de revista

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