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Título
Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis
Autor
Año del Documento
2011
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Revista Española de Cardiología, 2011;64(11):1056–1059
Résumé
The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide
polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4
(D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis.
The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by
means of restriction analysis after their amplification. An association between endocarditis and variants
of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found.
The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant
(odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype.
The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of
infective endocarditis. Further studies are required to validate these results and identify other genetic
risk factors.
Materias (normalizadas)
Endocarditis
ISSN
1885-5857
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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