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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/15414
Título: Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis
Autor: Bustamante, Juan
Tamayo Gómez, Eduardo
Flórez, Santiago
Tellería Orriols, Juan José
Bustamante, Elena
López, Javier
San Román Calvar, José Alberto
Álvarez, Francisco Javier
Año del Documento: 2011
Editorial: Elsevier
Descripción: Producción Científica
Documento Fuente: Revista Española de Cardiología, 2011;64(11):1056–1059
Resumen: The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors.
Materias (normalizadas): Endocarditis
ISSN: 1885-5857
Revisión por Pares: SI
DOI: 10.1016/j.rec.2011.02.027
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/15414
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP05 - Artículos de revista

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