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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24420

    Título
    Chitosan-recombinamer layer-by-layer coatings for multifunctional implants
    Autor
    Govindharajulu, Jeevan Prasaad
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Battacharya, Mrinal
    Aparicio, Conrado
    Año del Documento
    2017
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    International Journal of Molecular Sciences 2017, 18 (2), 369;
    Résumé
    The main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environment
    Palabras Clave
    Implante dental
    Revisión por pares
    SI
    DOI
    10.3390/ijms18020369
    Patrocinador
    Ministerio de Economía, Industria y Competitividad (Project MAT2013-42473-R and MAT2015-68901R)
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13, VA313U14 and VA015U16)
    Patrocinador
    info:eu-repo/grantAgreement/EC/FP7/278557
    info:eu-repo/grantAgreement/EC/FP7/317306
    info:eu-repo/grantAgreement/EC/H2020/642687
    info:eu-repo/grantAgreement/EC/H2020/646075
    Version del Editor
    http://www.mdpi.com/journal/ijms
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/24420
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Chitosan-Recombinamer.pdf
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    4.652Mo
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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