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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24816

    Título
    Gelatin-Hyaluronic Acid Hydrogels with Tuned Stiffness to Counterbalance Cellular Forces and Promote Cell Differentiation
    Autor
    Poveda Reyes, Sara
    Moulisova, Vladimira
    Sanmartín Masiá, Esther
    Quintanilla Sierra, LuisAutoridad UVA
    Salmerón Sánchez, Manuel
    Gallego Ferrer, Gloria
    Año del Documento
    2016
    Editorial
    Wiley
    Descripción
    Producción Científica
    Documento Fuente
    Macromolecular Bioscience, 2016, 16(9), pg. 1311-24
    Zusammenfassung
    Cells interact mechanically with their environment, exerting mechanical forces that probe the extracellular matrix (ECM). The mechanical properties of the ECM determine cell behavior and control cell differentiation both in 2D and 3D environments. Gelatin (Gel) is a soft hydrogel into which cells can be embedded. This study shows significant 3D Gel shrinking due to the high traction cellular forces exerted by the cells on the matrix, which prevents cell differentiation. To modulate this process, Gel with hyaluronic acid (HA) has been combined in an injectable crosslinked hydrogel with controlled Gel–HA ratio. HA increases matrix stiffness. The addition of small amounts of HA leads to a significant reduction in hydrogel shrinking after cell encapsulation (C2C12 myoblasts). We show that hydrogel stiffness counterbalanced traction forces of cells and this was decisive in promoting cell differentiation and myotube formation of C2C12 encapsulated in the hybrid hydrogels.
    Palabras Clave
    Gelatina
    Ácido hialurónico
    Revisión por pares
    SI
    DOI
    10.1002/mabi.201500469
    Patrocinador
    Ministerio de Economía, Industria y Competitividad (MAT2013-46467-C4-1-R)
    CIBER-BBN y el Instituto de Salud Carlos III mediante el Centro de Medicina Regenerativa y Terapia Celular de Castilla y León
    Version del Editor
    http://onlinelibrary.wiley.com/doi/10.1002/mabi.201500469/abstract
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/24816
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Gelatin Hyaluronic.pdf
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