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dc.contributor.author | Lopes, Joana | |
dc.contributor.author | Mustapa, Ana Najwa Binti | |
dc.contributor.author | Pantic, Milica | |
dc.contributor.author | Bermejo Roda, Maria Dolores | |
dc.contributor.author | Martín Martínez, Ángel | |
dc.contributor.author | Novak, Zoran | |
dc.contributor.author | Knez, Zeljko | |
dc.contributor.author | Cocero Alonso, María José | |
dc.date.accessioned | 2017-10-05T10:22:29Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22 | es |
dc.identifier.issn | 0896-8446 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/26138 | |
dc.description | Producción Científica | es |
dc.description.abstract | The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier B.V. | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Materiales | es |
dc.subject.classification | Supercritical | es |
dc.subject.classification | Impregnation | es |
dc.subject.classification | Aerogel | es |
dc.subject.classification | Phytol | es |
dc.subject.classification | Cellulose | es |
dc.subject.classification | Ionic liquids | es |
dc.title | Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Elsevier B.V. | es |
dc.identifier.doi | 10.1016/j.supflu.2017.07.018 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.supflu.2017.07.018 | es |
dc.identifier.publicationfirstpage | 17 | es |
dc.identifier.publicationlastpage | 22 | es |
dc.identifier.publicationtitle | The Journal of Supercritical Fluids | es |
dc.identifier.publicationvolume | 130 | es |
dc.peerreviewed | SI | es |
dc.description.embargo | 2019-07-25 | es |
dc.description.lift | 2019-07-25 | |
dc.description.project | Junta de Castilla y León VA295U14 | es |
dc.description.project | Marie Curie Program. Project DoHip | es |
dc.description.project | Ministerio de Economía. Programa Ramon y Cajal, RyC RYC-2013-13976 | es |
dc.description.project | MOE (Ministry of Education of Malaysia) | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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