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Título
Are Kv channels the essence of O2 sensing?
Año del Documento
2000
Editorial
American Heart Association
Descripción
Producción Científica
Documento Fuente
Circulation Research, 2000, vol. 86, n. 5. p. 490-491
Abstract
This report represents a relevant contribution to the study of oxygen sensing for two main reasons. First, it shows an approach adequate for identification of a putative O2-sensitive K+ channel, by moving from the modulation by hypoxia of a recombinant channel back to its physiological context, the role of this channel in the response to low Po2 of the native cells. Second, it demonstrates that hypoxic inhibition of the recombinant Kv3.1 channels is retained in excised membrane patches, pointing to a membrane-delimited mechanism as the origin of hypoxic responses. The importance of this latter finding deserves additional comment.
Palabras Clave
Potassium channels
Canales de potasio
Oxygen sensing
Detección de oxígeno
ISSN
1524-4571
Revisión por pares
SI
Version del Editor
Propietario de los Derechos
© 2000 American Heart Association
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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