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Título
HIV-2 viral tropism influences CD4+ T cell count regardless of viral load
Autor
Año del Documento
2014
Editorial
Oxford University Press
Descripción
Producción Científica
Documento Fuente
Journal of Antimicrobial Chemotherapy, 2014, vol. 69, n. 8, p. 2191-2194
Abstract
Background:HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in compari-son with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails toprovide optimal CD4 recovery.Methods:We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viraltropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA.Results:From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%).Patients with X4 viruses had lower median CD4+cell counts than patients with R5 viruses [130 (17 – 210) versus359 (180 – 470) cells/mm3;P¼0.007]. This was true even considering only the subset of 19 patients on antiretro-viral therapy [94 (16 – 147) versus 184 (43 – 368) cells/mm3;P¼0.041]. In multivariate analysis, significant differ-ences in CD4+cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender,antiretroviral therapy and viral load.Conclusions:The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+cell counts, regard-less of antiretroviral treatment. Along with CD4+cell counts, viral tropism testing may assist decisions aboutwhen to initiate antiretroviral therapy in HIV-2-infected individuals.
Materias Unesco
32 Ciencias Médicas
Palabras Clave
Antagonistas
Carga proviral
Maraviroc
ISSN
0305-7453
Revisión por pares
SI
Patrocinador
Fundación Investigación y Educación en Sida. (RIS, ISCIII-RETICRD/12/0017/0031)
Fondo de Investigación Sanitaria (FIS, PI10/00520)
Ministerio de Salud Consumo y Bienestar Social (EC10/277)
Ministerio de Ciencia e Innovación (MICINN, SAF2010/22232)
El proyecto Europeo CHAIN (FP7-223131)
Fondo de Investigación Sanitaria (FIS, PI10/00520)
Ministerio de Salud Consumo y Bienestar Social (EC10/277)
Ministerio de Ciencia e Innovación (MICINN, SAF2010/22232)
El proyecto Europeo CHAIN (FP7-223131)
Version del Editor
Propietario de los Derechos
© Oxford University Press
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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