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dc.contributor.authorFischer, Jan
dc.contributor.authorGonzález Martín, Javier
dc.contributor.authorLochyński, Paweł
dc.contributor.authorDejmková, Hana
dc.contributor.authorSchwarzová Pecková, Karolina
dc.contributor.authorVega, Marisol
dc.date.accessioned2021-06-04T10:12:37Z
dc.date.available2021-06-04T10:12:37Z
dc.date.issued2020
dc.identifier.citationJournal of Electroanalytical Chemistry, 2020, vol. 863, p. 114054es
dc.identifier.issn1572-6657es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/46746
dc.descriptionProducción Científicaes
dc.description.abstractTerconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in its molecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L−1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 μmol L−1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD ~ 4%) and detection limits reaching 0.50 μmol L−1 and 1.23 μmol L−1, respectively.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationVoltamétricoes
dc.subject.classificationTerconazoles
dc.titleVoltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materialses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2020 Elsevieres
dc.identifier.doi10.1016/j.jelechem.2020.114054es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S157266572030237Xes
dc.identifier.publicationfirstpage114054es
dc.identifier.publicationtitleJournal of Electroanalytical Chemistryes
dc.identifier.publicationvolume863es
dc.peerreviewedSIes
dc.description.projectCzech Science Foundation (project 18-01710S) and carried out within the framework of Specific University Research (SVV 260440)es
dc.description.projectJunta de Castilla y León y EU-FEDER (CLU 2017-09)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones
dc.subject.unesco23 Químicaes
dc.subject.unesco24 Ciencias de la Vidaes


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