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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50768

    Título
    Heterogeneity of induction therapy in Spain: changing patterns according to year, centre, indications and results
    Autor
    Rodrigo Calabia, Emilio
    Fernandez Fresnedo, Gema
    Robledo Zulet, Carmen
    Palomar Fontanet, Rosa
    Cantarell Aixandri, María del Carmen
    Mazuecos Blanca, Auxiliadora
    Osuna Ortega, Antonio
    Mendiluce Herrero, AliciaAutoridad UVA
    Alarcón Zurita, Antonio
    Arias Rodriguez, Manuel
    Año del Documento
    2010
    Editorial
    Oxford University Press
    Descripción
    Producción Científica
    Documento Fuente
    NDT Plus, 2010, vol. 3, supl. 2, p. 9-14
    Abstract
    Background. The use of induction drugs has increased markedly over the last 15 years in the USA, but there are few data about their use in other countries. Moreover, there are not enough data about when they are indicated and their long-term effects. The aim of our study was to know the rates of use and the drugs used as induction therapy, in which patients they were prescribed and the long-term graft survival effect in Spain. Methods. We conducted a retrospective cohort study with adult patients (4861) receiving a kidney allograft in Spain over four different years (1990, 1994, 1998 and 2002) with a functioning graft at the end of the first post-transplant year. Induction therapy was defined as when the patient received polyclonal antibodies, OKT3 monoclonal antibodies or anti-CD25 monoclonal antibodies. Results. From 1990 to 2002, the use of induction therapy in Spain changed, with a progressive reduction in the use of OKT3 and an increasing use of anti-CD25 antibodies. There were great differences in the rate of induction use from one centre to another, although with a common trend to greater use at each centre. Induction therapy was mainly prescribed in patients with a higher rejection risk (higher panel reactive antibody (PRA) titres and mismatches and re-transplants) and in older and diabetic recipients. Lastly, patients who were treated with induction therapy had significant higher allograft survival than those who did not (P value = 0.035). Conclusions. The use of induction therapy in Spain has changed, with an increasing use of monoclonal antibodies in recent years. Induction therapy has a protective role in long-term graft survival.
    Materias (normalizadas)
    Riñones - Trasplante
    Riñones - Enfermedades - Tratamiento
    Materias Unesco
    3205.06 Nefrología
    Palabras Clave
    Induction therapy
    ISSN
    1753-0784
    Revisión por pares
    SI
    DOI
    10.1093/ndtplus/sfq066
    Version del Editor
    https://academic.oup.com/ckj/article/3/suppl_2/ii9/447413
    Propietario de los Derechos
    © 2010 Oxford University Press
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/50768
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP52 - Artículos de revista [55]
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