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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50919

    Título
    Impact on outcomes across KDIGO-2012 AKI criteria according to baseline renal function
    Autor
    Acosta Ochoa, María Isabel
    Bustamante Munguira, JuanAutoridad UVA Orcid
    Mendiluce Herrero, AliciaAutoridad UVA
    Bustamante Bustamante, JesúsAutoridad UVA
    Coca Rojo, ArmandoAutoridad UVA
    Año del Documento
    2019
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Clinical Medicine (JCM), 2019, vol. 8, n. 9, 1323
    Resumen
    Acute kidney injury (AKI) and Chronic Kidney Disease (CKD) are global health problems. The pathophysiology of acute-on-chronic kidney disease (AoCKD) is not well understood. We aimed to study clinical outcomes in patients with previous normal (pure acute kidney injury; P-AKI) or impaired kidney function (AoCKD) across the 2012 Kidney Disease Improving Global Outcomes (KDIGO) AKI classification. We performed a retrospective study of patients with AKI, divided into P-AKI and AoCKD groups, evaluating clinical and epidemiological features, distribution across KDIGO-2012 criteria, in-hospital mortality and need for dialysis. One thousand, two hundred and sixty-nine subjects were included. AoCKD individuals were older and had higher comorbidity. P-AKI individuals fulfilled more often the serum creatinine (SCr) > 3.0x criterion in AKI-Stage3, AoCKD subjects reached SCr > 4.0 mg/dL criterion more frequently. AKI severity was associated with in-hospital mortality independently of baseline renal function. AoCKD subjects presented higher mortality when fulfilling AKI-Stage1 criteria or SCr > 3.0x criterion within AKI-Stage3. The relationship between mortality and associated risk factors, such as the net increase of SCr or AoCKD status, fluctuated depending on AKI stage and stage criteria sub-strata. AoCKD patients that fulfil SCr increment rate criteria may be exposed to more severe insults, possibly explaining the higher mortality. AoCKD may constitute a unique clinical syndrome. Adequate staging criteria may help prompt diagnosis and administration of appropriate therapy.
    Materias (normalizadas)
    Riñones - Enfermedades
    Chronic renal failure
    Insuficiencia renal crónica
    Materias Unesco
    3205.06 Nefrología
    ISSN
    2077-0383
    Revisión por pares
    SI
    DOI
    10.3390/jcm8091323
    Version del Editor
    https://www.mdpi.com/2077-0383/8/9/1323
    Propietario de los Derechos
    © 2019 MDPI
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/50919
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [181]
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    Universidad de Valladolid

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