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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50969

    Título
    The impact of donor age on the results of renal transplantation
    Autor
    Oppenheimer Salinas, Federico
    Aljama García, Pedro
    Asensio Peinado, Concepción
    Bustamante Bustamante, JesúsAutoridad UVA
    Crespo Albiach, Jose Francisco
    Guirado Perich, Luis
    Año del Documento
    2004
    Editorial
    Oxford University Press
    European Renal Association
    Descripción
    Producción Científica
    Documento Fuente
    Nephrology Dialysis Transplantation, 2004, vol. 19, supl. 3, p. 11–15
    Resumen
    Background. The use of elderly donors is becoming more frequent. An increase in the donor’s age is associated with a greater incidence of delayed graft function (DGF), chronic allograft nephropathy (CAN) and worse graft survival. Poor renal graft function is a risk factor for cardiovascular (CV) complications and, finally, for mortality of the patients. Methods. A total of 3365 adult patients transplanted in 1990 (n¼824), 1994 (n¼1075) and 1998 (n¼1466) with a functioning graft after the first year were included. The impact of donor age on renal function, DGF, acute rejection and other clinical factors was evaluated according to two donor and recipient age categories: young (<60 years old) and elderly (>60 years old). Additionally, donor age was categorized by decades for the analysis of patient and graft survival, acute rejection and CV mortality. Results. Donor mean age significantly increased during the three transplantation periods. A total of 478 out of 3365 donors were older than 60 years. Elderly donors showed an increased risk of DGF (38.9 vs 28.8%) and CAN (56.8 vs 46.2%). Mean serum creatinine at 3 and 12 months and proteinuria were significantly higher in the old donor group. Incidence and severity of acute rejection were similar in both groups. Graft and patient survival were significantly lower in the old donor group. Also, risk of mortality due to CV events was also significantly higher. A linear increase in risk of graft loss, patient death or CV mortality was observed when donor age was divided into 10 year increase subsets. Conclusions. Donor age is a strong predictor of CAN and graft loss. Patient survival is also affected by donor age, particularly by a higher risk of CV mortality.
    Materias (normalizadas)
    Riñones - Trasplante
    Survival
    Supervivencia
    Riñones - Enfermedades
    Materias Unesco
    3205.06 Nefrología
    3205.01 Cardiología
    Palabras Clave
    Cardiovascular risk
    Riesgo cardiovascular
    ISSN
    0931-0509
    Revisión por pares
    SI
    DOI
    10.1093/ndt/gfh1008
    Version del Editor
    https://academic.oup.com/ndt/article/19/suppl_3/iii11/1826911
    Propietario de los Derechos
    © 2004 Oxford University Press
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/50969
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [181]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional

    Universidad de Valladolid

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