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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50974

    Título
    Genetically engineered elastin-like recombinamers with sequence-based molecular stabilization as advanced bioinks for 3D bioprinting
    Autor
    Salinas Fernández, Soraya
    Santos García, María MercedesAutoridad UVA Orcid
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Quintanilla Sierra, LuisAutoridad UVA
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Applied Materials Today, 2020, vol. 18, 100500
    Resumo
    The versatility of 3D bioprinting techniques has demonstrated great potential for the development of artificial engineered tissues that more closely resemble native tissues. Despite this, challenges remain as regards the search for new bioinks that embrace all the complex parameters that this technique demands. In an attempt to develop such an advanced material, a novel smart material based on elastin-like recombinamers (ELRs) has been developed by molecularly programming its sequence to exhibit a sequential three-stage gelation process, thus providing printing attributes. The thermoresponsive behavior of the ELR is exploited for the deposition of well-controlled fibres on a platform heated to 37 °C, and its recombinant nature ensures batch-to-batch reproducibility and its applicability to a desired target tissue by the introduction of selected bioactive amino-acid sequences into its molecular chain. The biocompatible nature of the ELR enables the printing of loaded cells while providing a protective environment as part of the printing process. Thus, HFF-1 cells were found to be able to proliferate within the printed structures upon culture, displaying their natural morphology. The results of this work highlight the applicability and novelty of the bioprinting of biomimetic ELR-based structures for advanced applications.
    Palabras Clave
    Advanced materials
    Materiales avanzados
    Tissue engineering
    Ingeniería de tejidos
    Elastin like recombinamers
    Recombinantes tipo elastina
    ISSN
    2352-9407
    Revisión por pares
    SI
    DOI
    10.1016/j.apmt.2019.100500
    Patrocinador
    Gobierno de España (projects MAT2015-68901-R, MAT2016-78903-R and RTC-2018-096320-B-C22)
    Junta de Castilla y León (project VA317P18)
    Comisión Europea (project 0624_2IQBIONEURO_6_E)
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S2352940719306195?via%3Dihub
    Propietario de los Derechos
    © 2019 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/50974
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Genetically-engineered-elastin-like-recombinamers.pdf
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    Universidad de Valladolid

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