One of the more intriguing subjects in neuroscience is how a precursor or stem
cell is induced to differentiate into a neuron. Neurogenesis begins early in brain development
and suddenly becomes a very intense process, which is related with the influence of
Retinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that
―in vivo‖ embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic Isthmic
Retinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelial
precursors, inducing a significant increase in neurogenesis. This effect is mediated by the
Retinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge of
embryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
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