Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/57503
Título
Retinoic acid, under cerebrospinal fluid control, induces neurogenesis during early brain development
Autor
Año del Documento
2014
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Journal of Developmental Biology, 2014, vol. 2, n. 2, p. 72-83
Abstract
One of the more intriguing subjects in neuroscience is how a precursor or stem
cell is induced to differentiate into a neuron. Neurogenesis begins early in brain development
and suddenly becomes a very intense process, which is related with the influence of
Retinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that
―in vivo‖ embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic Isthmic
Retinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelial
precursors, inducing a significant increase in neurogenesis. This effect is mediated by the
Retinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge of
embryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
Materias Unesco
24 Ciencias de la Vida
32 Ciencias Médicas
Palabras Clave
Etinoic acid
Embryonic cerebrospinal fluid
Neurogenesis
ISSN
2221-3759
Revisión por pares
SI
Patrocinador
Ministerio de Educación y Ciencia (BFU207/6516)
Junta de Castilla y León (Consejería de Educación, GR195)
Junta de Castilla y León (Consejería de Educación, GR195)
Version del Editor
Propietario de los Derechos
© 2014 The Author(s)
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Collections
Files in this item
![http://creativecommons.org/licenses/by/3.0/](/themes/Mirage2//images/creativecommons/cc-by.png)