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Título
Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naı¨ve diabetes obese patients
Autor
Año del Documento
2010
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Diabetes Research and Clinical Practice, 2010, vol. 89, p. 110-114
Resumo
Background: The aim of the present study was to explore the relationship of resistin levels
with cardiovascular risk factors, insulin resistance and inflammation in naı¨ve diabetic
patients.
Subjects: A population of 66 naı¨ve diabetic patients with obesity was analyzed. A complete
nutritional and biochemical evaluation was performed.
Results: The mean age 56.9 11.6 years and the mean BMI was 37.8 6.3. Patients were
divided in two groups by median resistin value (3.3 ng/ml), group I (patients with the low
values, average value 2.5 0.5) and group II (patients with the high values, average value
4.8 1.8). Patients in the group I had lower waist circumference, total cholesterol, LDLcholesterol
and C-reactive protein than patients in group II. Correlation analysis showed a
significant correlation among resistin levels and the independent variables; BMI (r = 0.26;
p < 0.05), waist circumference (r = 0.38; p < 0.05), fat mass (r = 0.28; p < 0.05), LDL-cholesterol
(r = 0.3; p < 0.05), C-reactive protein (r = 0.28; p < 0.05). In the multivariate analysis, resistin
concentration increase 0.024 ng/ml (CI 95%: 0.006–0.42) for each mg/dl of C-reactive protein.
Conclusion: Circulating resistins are associated with C-reactive protein in an independent
way in naı¨ve diabetic patients.
Materias (normalizadas)
Cardiovascular, Aparato - Enfermedades
Diabetes
ISSN
0168-8227
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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