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    • SCIENTIFIC PRODUCTION
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    • Dpto. Biología Celular, Genética, Histología y Farmacología
    • DEP05 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/58972

    Título
    Unexpected toxicity of green tea polyphenols in combination with the Sambucus RIL ebulin
    Autor
    Rojo Rodriguez, María de los Ángeles
    Garrosa García, ManuelAutoridad UVA Orcid
    Jiménez López, María del PilarAutoridad UVA Orcid
    Girbés Juan, TomásAutoridad UVA Orcid
    García Recio, Verónica
    Córdoba Diaz, Manuel
    Córdoba Diaz, Damián
    Año del Documento
    2020
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Toxins, 2020, Vol. 12, Nº. 9, 542
    Abstract
    The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
    Materias (normalizadas)
    Polyphenols
    Té verde
    Lectinas
    Materias Unesco
    3214 Toxicología
    3206.11 Toxicidad de Los Alimentos
    Palabras Clave
    Sambucus ebulus
    Ebulin f
    RIP
    Ribosome-inactivating protein
    Ricin
    ISSN
    2072-6651
    Revisión por pares
    SI
    DOI
    10.3390/toxins12090542
    Patrocinador
    Junta de Castilla y León y Consejería de Sanidad (GR106)
    Version del Editor
    https://www.mdpi.com/2072-6651/12/9/542
    Propietario de los Derechos
    © 2020 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/58972
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Collections
    • DEP05 - Artículos de revista [127]
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    Unexpected-Toxicity-of-Green-Tea-Polyphenols.pdf
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    Atribución 4.0 InternacionalExcept where otherwise noted, this item's license is described as Atribución 4.0 Internacional

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