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Título
Unexpected toxicity of green tea polyphenols in combination with the Sambucus RIL ebulin
Autor
Año del Documento
2020
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Toxins, 2020, Vol. 12, Nº. 9, 542
Resumo
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
Materias (normalizadas)
Polyphenols
Té verde
Lectinas
Materias Unesco
3214 Toxicología
3206.11 Toxicidad de Los Alimentos
Palabras Clave
Sambucus ebulus
Ebulin f
RIP
Ribosome-inactivating protein
Ricin
ISSN
2072-6651
Revisión por pares
SI
Patrocinador
Junta de Castilla y León y Consejería de Sanidad (GR106)
Version del Editor
Propietario de los Derechos
© 2020 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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