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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59536

    Título
    Cell therapy for colorectal cancer: The promise of chimeric antigen receptor (CAR)-T cells
    Autor
    Aparicio Fernández, CristinaAutoridad UVA Orcid
    Belver Jiménez, Marina
    Enríquez, Lucía
    Espeso, Francisco
    Núñez Llorente, LucíaAutoridad UVA
    Sánchez García, Ana María de los ÁngelesAutoridad UVA Orcid
    Fuente García, Miguel Ángel de laAutoridad UVA Orcid
    González-Vallinas Garrachón, MargaritaAutoridad UVA
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    International Journal Molecular Science, 2021, vol. 22, n. 21, 11781
    Resumen
    Colorectal cancer (CRC) is a global public health problem as it is the third most prevalent and the second most lethal cancer worldwide. Major efforts are underway to understand its molecular pathways as well as to define the tumour-associated antigens (TAAs) and tumour-specific antigens (TSAs) or neoantigens, in order to develop an effective treatment. Cell therapies are currently gaining importance, and more specifically chimeric antigen receptor (CAR)-T cell therapy, in which genetically modified T cells are redirected against the tumour antigen of interest. This immunotherapy has emerged as one of the most promising advances in cancer treatment, having successfully demonstrated its efficacy in haematological malignancies. However, in solid tumours, such as colon cancer, it is proving difficult to achieve the same results due to the shortage of TSAs, on-target off-tumour effects, low CAR-T cell infiltration and the immunosuppressive microenvironment. To address these challenges in CRC, new approaches are proposed, including combined therapies, the regional administration of CAR-T cells and more complex CAR structures, among others. This review comprehensively summarises the current landscape of CAR-T cell therapy in CRC from the potential tumour targets to the preclinical studies and clinical trials, as well as the limitations and future perspectives of this novel antitumour strategy.
    Materias (normalizadas)
    Medicina
    Oncología
    Cancer Research
    Materias Unesco
    3201.01 Oncología
    Palabras Clave
    Colorectal cancer
    CAR-T cells
    Immunotherapy
    Neoantigens
    Cáncer colorrectal
    Células CAR-T
    Inmunoterapia
    Neoantígenos
    Revisión por pares
    SI
    DOI
    10.3390/ijms222111781
    Patrocinador
    Junta de Castilla y León (CCVC8485)
    Instituto de Salud Carlos III (RD16/0011/0003)
    Version del Editor
    https://www.mdpi.com/1422-0067/22/21/11781
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59536
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IBGM - Artículos de revista [78]
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    Nombre:
    Cell-Therapy-for-Colorectal-Cancer.pdf
    Tamaño:
    1.176Mb
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    Atribución 4.0 InternacionalLa licencia del ítem se describe como Atribución 4.0 Internacional

    Universidad de Valladolid

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