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    •   UVaDOC Startseite
    • WISSENSCHAFTLICHE ARBEITEN
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    • Edición Génica para el Estudio de Canales Iónicos Vasculares y Proteínas Mitocondriales (VASCUMIT)
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    • WISSENSCHAFTLICHE ARBEITEN
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    Citas

    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65379

    Título
    Kv channels and vascular smooth muscle cell proliferation
    Autor
    López López, José RamónAutoridad UVA Orcid
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Pérez García, María TeresaAutoridad UVA Orcid
    Año del Documento
    2018
    Documento Fuente
    Microcirculation. 2018; 25:e12427. https://doi.org/10.1111/micc.12427
    Zusammenfassung
    Kv channels are present in virtually all VSMCs and strongly influence contractile responses. However, they are also instrumental in the proliferative, migratory, and secretory functions of synthetic, dedifferentiated VSMCs upon PM. In fact, Kv channels not only contribute to all these processes but also are active players in the phenotypic switch itself. This review is focused on the role(s) of Kv channels in VSMC proliferation, which is one of the best characterized functions of dedifferentiated VSMCs. VSMC proliferation is a complex process requiring specific Kv channels at specific time and locations. Their identification is further complicated by their large diversity and the differences in expression across vascular beds. Of interest, both conserved changes in some Kv channels and vascular bed-specific regulation of others seem to coexist and participate in VSMC proliferation through complementary mechanisms. Such a system will add flexibility to the process while providing the required robustness to preserve this fundamental cellular response.
    ISSN
    1073-9688
    Revisión por pares
    SI
    DOI
    10.1111/micc.12427
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/65379
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    openAccess
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    • VASCUMIT - Artículos de revista [47]
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    Kv1.3_MTPG_revised.pdf
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    Universidad de Valladolid

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