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Título
Towards an efficient methodology for the synthesis of functionalized dihydropyrans by silyl-Prins cyclization: access to truncated natural products
Año del Documento
2024
Editorial
RSC
Documento Fuente
RSC Adv., 2024, 14, 707–711
Resumen
We herein present a selective methodology for the synthesis of disubstituted dihydropyrans by silyl-Prins cyclization of Z-vinylsilyl alcohols mediated by trimethylsilyl trifluoromethanesulfonate (TMSOTf). The reaction features broad substrate scope, short reaction times and ease of process scale-up. Moreover, to showcase the applicability of the proposed method, we also report a facile and linear synthesis of analogues of rhopaloic acid and natural doremox fragrance.
Revisión por pares
SI
Idioma
eng
Tipo de versión
info:eu-repo/semantics/draft
Derechos
openAccess
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