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Title: Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions
Authors: Bajo Grañeras, Raquel
Crespo Sanjuan, Jesús
García Centeno, Rosa M.
Garrote Adrados, José Antonio
Gutierrez, Gabriel
García Tejeiro, Manuel
Aguirre Cervás, Beatriz
Calvo Nieves, María D.
Bustamante, Rosa
Ganfornina Álvarez, María Dolores
Sánchez Romero, Diego
Issue Date: 2013
Publisher: Springer-Verlag
Description: Producción Científica
Citation: International Journal of Colorectal Disease, 2013, p. 1-18
Abstract: Purpose Inverse correlations of apolipoprotein D (ApoD) expression with tumor growth have been shown, therefore proposing ApoD as a good prognostic marker for diverse cancer types, including colorectal cancer (CRC). Besides, ApoD expression is boosted upon oxidative stress (OS) in many pathological situations. This study aims at understanding the role of ApoD in the progression of human CRC. Methods Samples of CRC and distant normal tissue (n051) were assayed for levels of lipid peroxidation, expression profile of OS-dependent genes, and protein expression. Three single-nucleotide polymorphisms in the ApoD gene were analyzed (n0139), with no significant associations found. Finally, we assayed the effect of ApoD in proliferation and apoptosis in the CRC HT-29 cell line.
Keywords: Colón - Cáncer - Tratamiento
ISSN: 0179-1958
Peer Review: SI
DOI: 10.1007/s00384-012-1616-2
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP06 - Artículos de revista

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