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    •   UVaDOC Home
    • SCIENTIFIC PRODUCTION
    • Departamentos
    • Dpto. Cirugía, Oftalmología, Otorrinolaringología y Fisioterapia
    • DEP11 - Artículos de revista
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    •   UVaDOC Home
    • SCIENTIFIC PRODUCTION
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    • Dpto. Cirugía, Oftalmología, Otorrinolaringología y Fisioterapia
    • DEP11 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/21595

    Título
    Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
    Autor
    Labrador Velandia, Sonia Cecilia
    Alonso Alonso, María Luz
    Álvarez Sánchez, Sara
    González Zamora, Jorge
    Pastor Jimeno, José CarlosAutoridad UVA
    Fernández Bueno, IvánAutoridad UVA
    Srivastava, Girish KumarAutoridad UVA Orcid
    Año del Documento
    2016
    Editorial
    Baishideng Publishing Group
    Descripción
    Producción Científica
    Documento Fuente
    World Journal of Stem Cells 2016, 26; 8(11), p. 376-383
    Abstract
    Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases
    Materias (normalizadas)
    Células madre
    Retina
    ISSN
    1948-0210
    Revisión por pares
    SI
    DOI
    10.4252/wjsc.v8.i11.376
    Patrocinador
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA066U13)
    Version del Editor
    http://www.wjgnet.com/1948-0210/index.htm
    Propietario de los Derechos
    © 2016 Baishideng Publishing Group Inc.
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/21595
    Derechos
    openAccess
    Collections
    • DEP11 - Artículos de revista [109]
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