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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/31345

    Título
    Functional EEG network analysis in schizophrenia: Evidence of larger segregation and deficit of modulation
    Autor
    Gómez Pilar, Javier
    Lubeiro Juárez, Alba
    Poza Crespo, JesúsAutoridad UVA Orcid
    Hornero Sánchez, RobertoAutoridad UVA Orcid
    Ayuso, Marta
    Valcarcel, César
    Haidar, Mahmoun-Karim
    Blanco Garrote, José AntonioAutoridad UVA Orcid
    Molina Rodríguez, VicenteAutoridad UVA Orcid
    Año del Documento
    2017
    Editorial
    Elsevier
    Documento Fuente
    Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 76, pp. 116-123, 2017.
    Abstract
    Objective: Higher mental functions depend on global cerebral functional coordination. Our aim was to study fast modulation of functional networks in schizophrenia that has not been previously assessed. Methods: Graph-theory was used to analyze the electroencephalographic (EEG) activity during an odd-ball task in 57 schizophrenia patients (18 first episode patients, FEPs) and 59 healthy controls. Clustering coefficient (CLC), characteristic path length (PL) and small-worldness (SW) were computed at baseline ([−300 0] ms prior to stimulus delivery) and response ([150 450] ms post-stimulus) windows. Clinical and cognitive assessments were performed. Results: CLC, PL and SW showed a significant modulation between baseline and response in controls but not in patients. Patients obtained higher CLC and SW at baseline, lower CLC and higher PL at response, and diminished modulation of CLC and SW as compared to controls. In patients, CLC and SW modulation were inversely associated to cognitive performance in executive tasks and directly associated to working memory. Similar patterns were observed in FEPs. CLC and SW during the baseline were inversely associated to their respective modulation magnitudes. Conclusions: Our results are coherent with a hyper-segregated network at baseline (higher CLC) and a decreased modulation of the functional connectivity during cognition in schizophrenia.
    Revisión por pares
    SI
    Patrocinador
    This work was supported by the Instituto Carlos III (PI11/02708, PI11/02203 and PI15/00299) and the Gerencia Regional de Salud de Castilla y León (GRS 1134/A/15 and GRS 1263/A/16) grants; the ‘MINECO and FEDER (TEC2014-53196-R), ‘Consejería de Educación de la Junta de Castilla y León’ (VA037U16); and predoctoral fellowships to A. Lubeiro (‘Consejería de Educación Junta de Castilla y León’) and to J. Gomez-Pilar (University of Valladolid).
    Version del Editor
    https://www.journals.elsevier.com/progress-in-neuro-psychopharmacology-and-biological-psychiatry/
    Propietario de los Derechos
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/31345
    Derechos
    restrictedAccess
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    • GIB - Artículos de revista [24]
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