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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/63829

    Título
    Functional network properties in schizophrenia and bipolar disorder assessed with high-density electroencephalography
    Autor
    Díez Revuelta, ÁlvaroAutoridad UVA
    Gómez Pilar, JavierAutoridad UVA Orcid
    Poza Crespo, JesúsAutoridad UVA Orcid
    Beño Ruiz De La Sierra, Rosa MaríaAutoridad UVA
    Fernández Linsenbarth, InesAutoridad UVA
    Recio Barbero, María
    Núñez Novo, PabloAutoridad UVA
    Holgado Madera, Pedro
    Molina Rodríguez, VicenteAutoridad UVA Orcid
    Año del Documento
    2024
    Documento Fuente
    Progress in Neuropsychopharmacology & Biological Psychiatry 129 (2024) 110902
    Resumen
    Background: The study of the cortical functional network properties in schizophrenia (SZ) may benefit from the use of graph theory parameters applied to high-density electroencephalography (EEG). Connectivity Strength (CS) assesses global synchrony of the network, and Shannon Graph Complexity (SGC) summarizes the network distribution of link weights and allows distinguishing between primary and secondary pathways. Their joint use may help in understanding the underpinnings of the functional network hyperactivation and task-related hypomodulation previously described in psychoses. Methods: We used 64-sensor EEG recordings during a P300 oddball task in 128 SZ patients (96 chronic, CR, and 32 first episodes, FE), as well as 46 bipolar disorder (BD) patients, and 92 healthy controls (HC). Pre-stimulus and modulation (task-response minus pre-stimulus windows values) of CS and SGC were assessed in the theta band (4–8 Hz) and the broadband (4–70 Hz). Results: Compared to HC, SZ patients (CR and FE) showed significantly higher pre-stimulus CS values in the broadband, and both SZ and BD patients showed lower theta-band CS modulation. SGC modulation values, both theta-band and broadband, were also abnormally reduced in CR patients. Statistically significant relationships were found in the theta band between SGC modulation and both CS pre-stimulus and modulation values in patients. CS altered measures in patients were additionally related to their cognitive outcome and negative symptoms. A primary role of antipsychotics in these results was ruled out. Conclusions: Our results linking SGC and CS alterations in psychotic patients supported a hyperactive and hypomodulatory network mainly involving connections in secondary pathways.
    ISSN
    0278-5846
    Revisión por pares
    SI
    DOI
    10.1016/j.pnpbp.2023.110902
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/63829
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [206]
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    Universidad de Valladolid

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