Background & aims: Omentin-1 might play a role on insulin resistance, dyslipidemia and obesity. The aim
of this investigation was to evaluate the influence of weight loss on omentin-1 concentrations after a
hypocaloric diet with Mediterranean pattern.
Methods: A Caucasian sample of 67 obese patients was analyzed before and after 3 months on a
hypocaloric diet. Anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein
(CRP), fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured.
Results: Sixty-seven obese subjects were enrolled in the study. The mean age was 48.3 ± 8.0 years
(range: 25e66) and the mean BMI 34.5 ± 4.8 kg/m2 (range: 30.2e40.8). Gender distribution was 50
females (74.6%) and 17 males (25.4%). After dietary intervention and in males and females; body mass
index, weight, fat mass, waist circumference, blood pressure, glucose, LDL cholesterol, insulin and
HOMA-IR decreased. Omentin-1 levels increase after dietary intervention (males vs females) (delta basal
vs 3 months: 10.0 ± 3.8 ng/dl: p ¼ 0.01 vs 9.9 ± 4.1 ng/dl; p ¼ 0.03). In the multiple regression analysis
adjusted for age and sex; BMI and insulin remained independently associated with baseline and posttreatment levels of omentin-1.
Conclusions: Our investigation showed a significant increase in omentin-1 levels after weight loss secondary to a hypocaloric diet with a Mediterranean pattern.
