Skip navigation
Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/21846
Título: Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system.
Autor: Inostroza Brito, Karla E.
Collin, Estelle
Siton Mendelson, Orit
Smith, Katherine H.
Monge Marcet, Amália
Ferreira, Daniela S.
Pérez Rodríguez, Raúl
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
Reis, Rui L.
Sagués, Francesc
Botto, Lorenzo
Bitton, Ronit
Azevedo, Helena S.
Mata, Álvaro
Año del Documento: 2015
Editorial: Nature Publishing Group
Descripción: Producción Científica
Documento Fuente: Nature Chemistry, 2015, vol. 7, p. 897–904
Resumen: Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non- equilibrium for substantial periods of time. The system enables the formation of a robust membrane that displays controlled assembly and disassembly capabilities, adhesion and sealing to surfaces, self-healing and the capability to undergo morphogenesis into tubular structures with high spatiotemporal control. We use advanced microscopy along with turbidity and spectroscopic measurements to investigate the mechanism of assembly and its relation to the distinctive membrane architecture and the resulting dynamic properties. Using cell-culture experiments with endothelial and adipose- derived stem cells, we demonstrate the potential of this system to generate complex bioactive scaffolds for applications such as tissue engineering.
Materias (normalizadas): Moléculas - Propiedades
ISSN: ISSN: 1755-4330
Revisión por Pares: SI
DOI: 10.1038/nchem.2349
Patrocinador: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
Version del Editor: http://www.nature.com/natrevchem/
Idioma: spa
URI: http://uvadoc.uva.es/handle/10324/21846
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP60 - Artículos de revista

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Co-assembly-spatiotemporal-control.pdf1,66 MBAdobe PDFThumbnail
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons

Comentarios
Universidad de Valladolid
Powered by MIT's. DSpace software, Version 5.5